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KMID : 0616619950010020127
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Journal of Soonchunhyang Medical College
1995 Volume.1 No. 2 p.127 ~ p.135
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DNCB test and defective function of T-lymphocytes in sixteen patients with psoriasis
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Abstract
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Immunological studies have been undertaken recently in psoriasis to clarify the concept of the autoimmunological pathogenesis of the disorder.
We have investigated quantitative changes of lymptocyte populations and immune responses of T-cell functions with DNCB sensitivity by the administration of prednisolone and methotrexate in sixteen patients with psoriasis compared with eight normal controls.
The results obtained were as follows:
1. Seven psoriasis patients among the sixteen cases were sensitized to DNCB. (43.8%)
2. The mean percentage of T-lymphocytes in prednisolone group were 55.0±3.4 %
3. The mean percentage of T-lymphocytes in methotrexate group were 62.0±2.4%
4. Prednisolone remarkably decreased T-lymphocytes, while methotrexate markedly decreased total leukocytes.
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